99Tcm标记异腈类配合物的研究进展

    摘　要：99Tcm标记的异腈类配合物是目前国内外应用最广泛的心肌灌注显像剂,在肿瘤的诊断方面也有重要应用.本文简要介绍了异腈配体    合成及标记化合物的制备方法,并对99Tcm标记异腈类配合物的发展、分类及应用进展作了归纳总结.
    关键词：锝;异腈;心肌;肿瘤;多药耐药
    分类号：R817 　文献标识码：A
    文章编号：1001-098X(2005)01-0019-04
 
    作者简介：通讯作者:王学斌
    作者单位：白旭东（100875,北京师范大学化学系放辐化研究室）　
　　　　　唐志刚（100875,北京师范大学化学系放辐化研究室）　
　　　　　王学斌（100875,北京师范大学化学系放辐化研究室）　

    参考文献：

    [1]Wackers FJT, Berman DS, Maddahi J, et al. Technetium-99m hexakis 2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety, and preliminary comparison[J]. J Nucl Med, 1989, 30(3): 301-311.
    [2]Zhang XZ, Wang XB, Jia F, et al. Preparation, characterization and biodistribution of a new technetium-99m nitrido complex with 2methoxyisobutylisonitrile and comparison with 99mTc-MIBI[J]. J Labelled cpd Radiopharm, 2002, 45(12): 1029-1043.
    [3]Hao GY, Zhang JY, Liu BL et al. Synthesis, separation and biodistribution of 99mTc-CO-MIBI complex[J]. J Labelled Cpd Radiopharm, 2004, 47(8): 513-521.
    [4]Zhang XZ, Wang XB, Tang ZG, et al. Effects of Tween-80 on thebiodistribution of several lipophilic technetium-99m complexes[J].Nucl Med Biol, 2001, 28(3): 303-308.
    [5]Pauwels EKJ, McCready VR, Stoot JHMB, et al. The mechanism of accumulation of tumour-localising radiopharmaceuticals[J]. Eur J Nucl Med, 1998, 25(3): 277-305.
    [6]Sciuto R, Pasqualoni R, Bergomi S, et al. Prognostic value of 99mTcsestamibi washout in predicting response of locally advanced breast cancer to neoadjuvant chemotherapy[J]. J Nucl Med 2002, 43(6):745-751.
    [7]Burak Z, Moretti JL, Ersoy O, et al. 99mTc-MIBI imaging as a predic tor of therapy response in osteosarcoma compared with multidrug resistance-associated protein and P-glycoprotein expression [J]. J Nucl Med, 2003, 44(9): 1394-1401.
    [8]Barbarics E, Kronauge JF, Jones AG, et al. Uptake of cationic technetium complexes in cultured human cacinoma cells and human xenografts[J]. Nucl Med Biol, 1998, 25(7): 667-673.
    [9]Dyszlewski M, Blake HM, Dahlheimer JL, et al. Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity[J]. Mol Imaging, 2002, 1(1): 24-35.