疾病专题:前列腺炎颈椎病高血压心内科糖尿病痛风冠心病宫颈疾病关节炎肝病癌症呼吸内科感冒神经内科分泌内科泌尿内科消化内科整形

自噬分子机制的研究动向

www.cnkang.com  2007-4-16 9:04:00  中华康网

  摘要 自噬是细胞对自身结构进行蛋白降解的一种方式。为从分子水平揭示细胞内部自噬调控机理,需研究该过程的各个环节。新近的研究,特别是近几年自噬基因的发现证实,蛋白磷酸化参与的自噬调控;自噬体膜的形成;微管系统传输自噬体以及自噬与凋亡的内在联系,都有分子水平的依据,这给更深入地研究自噬分子机理提供了重要的信息。

  参考文献

   1,Blommaart EF,Luiken JJ,Meijer AJ.Autophagic proteolysis:control and specificity.Histochem J,1997,29(5):365

  2,Haussinger. The role of cellular hydration in the regulation of cell function. Biochem J,1996,313:697

  3,Schlumpberger M,Schaeffeler E,Thumm M,et al. AUT1,a gene essential for autophagocytosis in the yeast Saccharomyces cerevisiae. J Bacteriol,1997,179(4):1068

  4,Hammond EM,Brunet CL,Grand RJ,et al. Homology between a human apoptosis specific protein and the product of APG5,a gene involved in autophagy in yeast. FEBS Lett,1998,425(3):391

  5,Straub M,Bredschneider M,Thumm M.AUT3,a serine/threonine kinase gene,is essential for autophagocytosis in Saccharomyces cerevisiae. J Bacteriol,1997,179(12):3875

  6,Matsuura A,Tsukada M,Ohsumi Y,et al.Apglp,a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene,1997,192(2):245

  7,Funakoshi T,Matsuura A,Ohsumi Y,et al.Analyses of APG13 gene involved in autophagy in yeast,Saccharomyces cerevisias. Gene,1997,192(2):207

  8,Kametaka S,Okano T,Ohsumi Y,et al.Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast,Saccharomyces cerevisiae. J Biol Chem,1998,273(35):22284

  9,Mizushima N,Noda T,Ohsumi Y, et al.A protein conjugation system essential for autophagy. Nature,1998,395(6700):321,323

  10,Lang T,Schaeffeler E,Thumm M,et al.Aut2p and Aut7p,two novel microtubule-associated proteins are essential for delivery of autophagic vesicles to the vacuole.EMBO J,1998,17(13):3597

  11,Seglen PO.DNA ploidy and autophagic protein degradation as determinants of hepatocellular growth and survival. Cell Biol Toxicol,1997,13(4-5):3

  12,Jia L,Dourmashkin RR,Kelsey SM,et al.Inhibition of autophagy abrogates tumour necrosis factor alpha induced apoptosis in human T-lymphoblastic leukaemic cells. Br J Haematol,1997,98(3):673

  13,Bursch W,Ellinger A,Hermann RS,et al.Active cell death induced by thje anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells(MCF-7) in culture:the role of autophagy. Carcinogenesis,1996,17(8):1595

  • 两性
  • 男人
  • 女性
  • 母婴